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Cohesion is a fundamental concept that denotes the state of unity, togetherness, and interconnectedness among individuals, groups, or entities. It represents the degree to which members within a collective entity are bound together by shared goals, values, and a sense of belonging. Key points regarding cohesion include:

  1. Unity and Solidarity: Cohesion is characterized by a sense of unity and solidarity, where individuals or groups come together to pursue common objectives, whether in social, organizational, or community settings.
  2. Social Bonds: It plays a pivotal role in strengthening social bonds and fostering a sense of belonging among individuals, contributing to a harmonious and supportive environment.
  3. Inclusivity: Cohesion promotes inclusivity by encouraging the acceptance and integration of diverse perspectives, backgrounds, and identities, fostering an atmosphere of respect and appreciation.
  4. Collective Identity: Cohesion often leads to the formation of a collective identity, where individuals identify with a larger group and share a sense of purpose and identity.
  5. Team Dynamics: In team settings, cohesion is a critical factor in team dynamics, as it enhances collaboration, communication, and mutual support among team members, leading to improved performance.
  6. Motivation and Commitment: Cohesion positively influences motivation and commitment, as individuals are more likely to invest time and effort in pursuits where they feel a strong sense of belonging and connection.
  7. Resilience: Cohesive groups are often more resilient in the face of challenges, as members draw strength from their bonds and are better equipped to overcome adversity.
  8. Conflict Resolution: Cohesion facilitates conflict resolution by promoting open communication, empathy, and a willingness to work together to address disagreements and find common ground.
  9. Community Engagement: In communities, cohesion is a catalyst for community engagement and collective action, where residents collaborate to address local issues, promote social welfare, and drive positive change.
  10. Organizational Success: Cohesive workplaces tend to be more productive and successful, as employees work cohesively, share a sense of purpose, and align their efforts with organizational goals.
  11. Trust and Communication: Trust and effective communication are integral components of cohesion, as they underpin the sense of unity and cooperation within groups.
  12. Social Capital: Cohesion generates social capital, a valuable resource that individuals and groups can leverage for mutual benefit, such as networking, resource-sharing, and support systems.
  13. Community Well-being: In broader society, cohesion contributes to community well-being by fostering social integration, reducing social isolation, and promoting a sense of belonging among residents.
  14. Cultural Significance: Cohesion has cultural significance, as it influences the formation of cultural norms, traditions, and shared values within societies and communities.
  15. Policy and Intervention: Governments and organizations often recognize the importance of cohesion and may implement policies and interventions to strengthen social bonds and promote inclusivity.
  16. Global Perspective: Cohesion extends to the global stage, where international cooperation and alliances are formed to address global challenges, such as climate change, peacekeeping, and humanitarian aid.

Cohesion serves as a foundational element for building strong, resilient, and thriving communities, organizations, and teams. It fosters a sense of connection and shared purpose that transcends individual interests, leading to enhanced collaboration, well-being, and the pursuit of common goals. Cultivating cohesion requires nurturing relationships, fostering open communication, and valuing diversity, ultimately contributing to a more inclusive and harmonious world.

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  582. Die konventionelle Zytogenetik ist bei der Diagnosestellung empfohlen, das
    Materials kann jedoch eventuell für spätere Testung asserviert werden. Aufgrund des
    im Allgemeinen indolenten Verlaufs der PV gehört eine erweiterte molekulare
    Untersuchung derzeit nicht zur Routine einer
    Abklärung. Dies ist jedoch in den Fällen mit grenzwertigem Erscheinungsbild, bei denen die Unterscheidung zu anderen MPN schwierig ist, oder
    bei denen der Verdacht auf ein Fortschreiten der Krankheit besteht, angezeigt.
    Die erweiterte Charakterisierung erfolgt mittels Next Technology Sequencing (NGS).
    Diese Untersuchung ist jedoch in der Regel mit höheren Kosten verbunden und bedarf einer Zustimmung
    der Krankenkasse mit einer Kostengutsprache. Die Betroffenen weisen quick immer
    eine Mutation im Gen JAK2 auf – dies, so sollte sich später herausstellen, warfare bei dem
    Patient nicht der Fall. Wegen des erhöhten Thromboserisikos für
    die Patientin und den Fetus (erhöhte Spontanabortrate, Plazentarinfarkt/-insuffizienz) ist aber eine intensive interdisziplinäre Betreuung erforderlich, die in intestine 50 % zu Lebendgeburten führen kann.

    Diese sekundären Polyzythämien sind eine physiologische Antwort
    auf die entstehende Gewebehypoxie. Informieren Sie sich
    täglich (montags bis freitags) per E-Mail über das aktuelle
    Geschehen aus der Gesundheitspolitik und der Medizin. Bestellen Sie den kostenfreien E-newsletter des Deutschen Ärzteblattes.

    Der Prozess der Andropause und ihre hormonellen Veränderungen verläuft langsamer
    – quasi schleichend – und wird daher häufig nicht erkannt.
    Bei unbehandeltem Prostatakrebs sollte auf eine Testosteron­substitution verzichtet werden. Auch bei den extrem seltenen Fällen von männlichem Brustkrebs sollte keine Testosteron­behandlung erfolgen. neben Effekte von testosteron;
    needingjob.com,
    Erythropoetin ist auch Cortisol ein Erythropoese-stimulierendes Hormon. Erhöhte
    Cortisolspiegel als Ausdruck eines Cushing-Syndroms
    oder eines Morbus Cushing können somit ebenfalls eine Polyglobulie verursachen.
    Der Blutdruck sank in den Normbereich, ebenso sanken der Hämatokrit
    und das Hämoglobin. Hier wird gewichtsadaptiert ein Aderlass durchgeführt
    und mit isotonischer Kochsalzlösung substituiert.
    Bei einer absoluten Polyglobulie erfolgt die weitere diagnostische Abklärung der Grunderkrankung.

    Dazu zählen unter anderem die Kardiodiagnostik mittels Echokardiographie,
    der Röntgenthorax, die Sonographie und ggf. Durch hohe Flüssigkeitsverluste nach lang andauerndem Erbrechen oder
    massiven Diarrhoen ändert sich das Zell-Plasma-Verhältnis.

    Ursache der Testosteron-bedingten Polyglobulie ist vermutlich eine gehemmte Ausschüttung von Hepcidin, das an der
    Regulation des Eisenstoffwechsels beteiligt ist. Aus ungeklärten Gründen erhöht sich außerdem
    die Erythropoetin-Freisetzung. Es gibt auch Berichte
    über eine vermehrte inflammatorische Aktivität unter Testosteron-Substitution – dies könnte eine Erklärung für die beobachtete Leukozytose des Patienten sein. Zunächst jedoch behandelten die Schweizer Internisten den Patienten auf Grundlage der erhobenen Informationen wie einen Polycythaemia-Patienten. Er erhielt zur
    Thrombozytenaggregationshemmung Clopidogrel und wurde mehrfach zur Ader gelassen.
    Allerdings muss die Therapie wegen grippeähnlicher Symptome, Haarausfall und/oder psychiatrischer Störungen häufig abgebrochen werden (22).

    Werden die JAK2-spezifischen Mutationen nicht nachgewiesen und
    ist der EPO-Spiegel regular oder erhöht, ist eine PV unwahrscheinlich.
    In diesem Fall sollte nach Tumoren, die zu einer EPO-Erhöhung führen können, gesucht und eine primäre Polyzythämie ausgeschlossen werden. Ist die JAK2V617F-Mutation nicht
    vorhanden und der EPO-Spiegel erniedrigt, sollte danach das
    Exon 12 auf Mutationen untersucht werden.
    Labordiagnostisch zeigt sich das Bild einer Polyglobulie, das jedoch nur vorgetäuscht ist, da in Wirklichkeit
    ein Flüssigkeitsmangel und damit eine Dehydratation vorliegt.
    Eine Polyglobulie ist eine Erhöhung der Zahl der roten Blutkörperchen (Erythrozyten) über den physiologischen Normwert.
    Sie macht sich labordiagnostisch durch einen erhöhten Hämatokrit bemerkbar.
    Prof. Dr. Petrides hat Vortragshonorare von den Firmen Shire und AOP erhalten. Herr Siegel erklärt,
    dass kein Interessenkonflikt im Sinne des Worldwide Committee of Medical Journal Editors besteht.
    Der wasserinduzierte Juckreiz ist das chronische Symptom der PV, welches die Lebensqualität am stärksten beeinträchtigt.

    Aus dieser Beobachtung heraus resultierte die Angst, dass die Substitution mit Testosteron das Wachstum
    einer bisher nicht erkannten Prostata­krebs­erkrankung
    beschleunigen könne. Weder wurde vermehrt Prostata­krebs unter
    einer Testosteron­substitutions­therapie diagnostiziert,
    noch besteht bei Männern mit hohen Testosteron­spiegeln eine erhöhte Tumorinzidenz.
    Hohes Testosteron wird häufig mit vermehrtem Haarausfall in Verbindung gebracht.
    Ein Zusammenhang, der in dieser monokausalen Type nicht besteht.Eine hormonelle Ursache
    für verstärkten Haarausfall kann allerdings eine Erhöhung des Hormons Dihydrotes­tosteron (DHT) sein.

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  588. Balanset-1A: Cutting-edge Mobile Balancer & Vibration Analyzer
    Industrial-grade Dynamic Balancing Solution
    Balanset-1A constitutes an innovative solution for dynamic balancing of rotors in their own bearings, engineered by Estonian company Vibromera OU. The device provides professional equipment balancing at €1,751, which is substantially less expensive than traditional vibration analyzers while preserving superior measurement accuracy. The system allows on-site balancing directly at the equipment’s installation site without requiring removal, which is vital for reducing production downtime.
    About the Manufacturer
    Vibromera OU is an Estonian company focusing in the design and production of devices for technical diagnostics of industrial equipment. The company is incorporated in Estonia (registration number 14317077) and has branches in Portugal.
    Contact Information:

    Official website: https://vibromera.eu/shop/2/

    Technical Specifications
    Measuring Parameters
    Balanset-1A delivers precise measurements using a dual-channel vibration analysis system. The device measures RMS vibration velocity in the range of 0-80 mm/s with an accuracy of ±(0.1 + 0.1?Vi) mm/s. The working frequency range is 5-550 Hz with optional extension to 1000 Hz. The system supports rotational speed measurement from 250 to 90,000 RPM with phase angle determination accuracy of ±1 degree.
    Working Principle
    The device employs phase-sensitive vibration measurement technology with MEMS accelerometers ADXL335 and laser tachometry. Two single-axis accelerometers measure mechanical vibrations proportional to acceleration, while a laser tachometer generates pulse signals for determining RPM and phase angle. Digital signal processing includes FFT analysis for frequency analysis and proprietary algorithms for automatic calculation of corrective masses.
    Full Kit Package
    The standard Balanset-1A delivery includes:

    Measurement unit with USB interface – primary module with built-in preamplifiers, integrators, and ADC
    2 vibration sensors (accelerometers) with 4m cables (alternatively 10m)
    Optical sensor (laser tachometer) with 50-500mm measuring distance
    Magnetic stand for sensor mounting
    Electronic scales for exact measurement of corrective masses
    Software for Windows 7-11 (32/64-bit)
    Plastic transport case
    Complete set of cables and documentation

    Performance Capabilities
    Vibrometer Mode
    Balanset-1A functions as a full-featured vibration analyzer with features for measuring overall vibration level, FFT spectrum analysis up to 1000 Hz, determining amplitude and phase of the fundamental frequency (1x), and continuous data recording. The system delivers display of time signals and spectral analysis for equipment condition diagnostics.
    Balancing Mode
    The device supports one-plane (static) and two-plane (dynamic) balancing with automatic calculation of corrective masses and their installation angles. The unique influence coefficient saving function enables substantial acceleration of follow-up balancing of identical equipment. A dedicated grinding wheel balancing mode uses the three-correction-weight method.
    Software
    The user-friendly program interface provides step-by-step guidance through the balancing process, making the device usable to personnel without special training. Key functions include:

    Automatic tolerance calculation per ISO 1940
    Polar diagrams for imbalance visualization
    Result archiving with report generation capability
    Metric and imperial system support
    Multilingual interface (English, German, French, Polish, Russian)

    Application Areas and Equipment Types
    Industrial Equipment
    Balanset-1A is successfully applied for balancing fans (centrifugal, axial), pumps (hydraulic, centrifugal), turbines (steam, gas), centrifuges, compressors, and electric motors. In manufacturing facilities, the device is used for balancing grinding wheels, machine spindles, and drive shafts.
    Agricultural Machinery
    The device provides particular value for agriculture, where reliable operation during season is essential. Balanset-1A is applied for balancing combine threshing drums, shredders, mulchers, mowers, and augers. The capability to balance on-site without equipment disassembly enables preventing costly downtime during peak harvest periods.
    Specialized Equipment
    The device is effectively used for balancing crushers of various types, turbochargers, drone propellers, and other high-speed equipment. The RPM frequency range from 250 to 90,000 RPM covers essentially all types of industrial equipment.
    Advantages Over Alternatives
    Economic Effectiveness
    At a price of €1,751, Balanset-1A offers the functionality of devices costing €10,000-25,000. The investment breaks even after preventing just 2-3 bearing failures. Cost reduction on external balancing specialist services totals thousands of euros annually.
    Ease of Use
    Unlike sophisticated vibration analyzers requiring months of training, mastering Balanset-1A takes 3-4 hours. The step-by-step guide in the software allows professional balancing by personnel without specific vibration diagnostics training.
    Mobility and Autonomy
    The complete kit weighs only 4 kg, with power supplied through the laptop’s USB port. This permits balancing in field conditions, at remote sites, and in inaccessible locations without external power supply.
    Versatile Application
    One device is suitable for balancing the most extensive spectrum of equipment – from small electric motors to large industrial fans and turbines. Support for single and two-plane balancing covers all typical tasks.
    Real Application Results
    Drone Propeller Balancing
    A user achieved vibration reduction from 0.74 mm/s to 0.014 mm/s – a 50-fold improvement. This demonstrates the outstanding accuracy of the device even on small rotors.
    Shopping Center Ventilation Systems
    Engineers successfully balanced radial fans, achieving lower energy consumption, eliminated excessive noise, and extended equipment lifespan. Energy savings recovered the device cost within several months.
    Agricultural Equipment
    Farmers note that Balanset-1A has become an vital tool preventing costly breakdowns during peak season. Decreased vibration of threshing drums led to decreased fuel consumption and bearing wear.
    Cost and Delivery Terms
    Current Prices

    Complete Balanset-1A Kit: €1,751
    OEM Kit (without case, stand, and scales): €1,561
    Special Offer: €50 discount for newsletter subscribers
    Wholesale Discounts: up to 15% for orders of 4+ units

    Ordering Options

    Official Website: vibromera.eu (recommended)
    eBay: certified sellers with 100% rating
    Industrial Distributors: through B2B channels

    Payment and Shipping Terms

    Payment Methods: PayPal, credit cards, bank transfer
    Shipping: 10-20 business days by international mail
    Shipping Cost: from $10 (economy) to $95 (express)
    Warranty: factory warranty
    Technical Support: included in price

    Final Assessment
    Balanset-1A stands as an perfect solution for organizations seeking to implement an effective equipment balancing system without significant capital expenditure. The device opens up access to professional balancing, allowing small enterprises and service centers to deliver services at the level of large industrial companies.
    The combination of affordable price, ease of use, and professional capabilities makes Balanset-1A an vital tool for modern technical maintenance. Investment in this device is an investment in equipment stability, decreased operating costs, and improved competitiveness of your enterprise.

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